Selected publications
Chen L*, Kang ZF*, Härdfeldt J, Li ZY, Pedrelli M, Li Q, Lyu RN, Allo PV, Zheng XR, Lin PB, Zeng JW, Huang ZQ, Garcia-Irigoyen O, Sukhanava S, Parini P, Bonnefond A, Angelin B, Treuter E, Fan R# Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes. Research Square https://doi.org/10.21203/rs.3.rs-6065505/v1.
A Efthymiadou, C Gu, C Wang, H Wang, Z Li, O Garcia-Irigoyen, R Fan, E Treuter#, Z huang# SMRT anchors the HDAC3 corepressor complex to chromatin to regulate inflammatory and metabolic pathways in macrophages. Nucleic Acids Research 2025. 53 (17), gkaf880
K Lin, L Wei, R Wang, L Li, S Song, F Wang, M He, W Pu, J Wang, J Wazir, W Cao, X Yang, E Treuter, R Fan, Y Wang, Z Huang#, H Wang# Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1. Cell Metabolism 2025. 37 (2), 460-476. e8.
AC Ludzki, M Hansen, D Zareifi, J Jalkanen, Z Huang, M Omar-Hmeadi, G Renzi, F Klingelhuber, S Boland, Y A Ambaw, N Wang, A Damdimopoulos, J Liu, T Jernberg, P Petrus, P Arner, N Krahmer, R Fan, E Treuter, H Gao, M Rydén#, N Mejhert# Transcriptional determinants of lipid mobilization in human adipocytes. Science Advances 2024. 10 (1), eadi2689
Z Huang, A Efthymiadou, N Liang, R Fan#, E Treuter# Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4. Nucleic Acids Research 2023. 51 (3), 1067-1086
Z Huang, N Liang, S Goni, A Damdimopoulos, C Wang, R Ballaire, J Jager, H Niskanen, H Han, T Jakobsson, Ad Bracken, M Aouadi, N Venteclef, M Kaikkonen, R Fan#, E Treuter# The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages. Molecular cell 2021. 81 (5), 953-968. e9
N Liang, A Damdimopoulos, S Goñi, Z Huang, LL Vedin, T Jakobsson, M Giudici, O Ahmed, M Pedrelli, S Barilla, Fa Alzaid, A Mendoza, T Schröder, R Kuiper, P Parini, A Hollenberg, P Lefebvre, S Francque, L Gaal, B Staels, N Venteclef, E Treuter#, R Fan#. Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα. Nature communications 2019. 10
Z Huang, N Liang, A Damdimopoulos, R Fan#, E Treuter#. G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. The FASEB Journal 2018. 33 (2), 1631-1643